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dc.creatorOlaya-C M.
dc.creatorMichael F.
dc.creatorFabian G.
dc.creatorLuis Silva J.
dc.creatorBernal J.E.
dc.creatorGarzon A.L.
dc.date.accessioned2020-03-26T16:33:11Z
dc.date.available2020-03-26T16:33:11Z
dc.date.issued2019
dc.identifier.citationJournal of Neonatal-Perinatal Medicine; Vol. 12, Núm. 1; pp. 47-56
dc.identifier.issn19345798
dc.identifier.urihttps://hdl.handle.net/20.500.12585/9192
dc.description.abstractINTRODUCTION: The umbilical cord (UC) is a vital structure; its alterations affect the newborn and neurological impact can be permanent. Paradoxically, factors that determine it remain unknown. We explore the differential VEGF protein expression in the UC's proximal and distal portions in relation to the hypothesis that the UC has differential growth and that VEGF plays a role in it. METHODS: An observational analytical study was performed. One UC segment was taken proximal to fetus and another distal; both were randomly processed; VEGF immunohistochemical analysis was performed; two blinded pathologists read results. RESULTS: Forty-eight newborns were included. Protein expression between the two edges of the umbilical cord, in any kind of cells, was interpreted. Endothelium, amnion, and stromal cells expressed VEGF; the first two were not different between opposite ends. Stromal cells had differential expression: higher in the proximal to the fetus portion. CONCLUSION: Knowledge of molecular factors is necessary. UC cells widely expressed VEGF, possibly contributing to UC growth. Even though stromal cell expression was different, the interaction with activity close to the fetus must be explored. © 2019 - IOS Press and the authors. All rights reserved.eng
dc.format.mediumRecurso electrónico
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherIOS Press
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourcehttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85064122819&doi=10.3233%2fNPM-1795&partnerID=40&md5=ebf42be72c3f52fa638593f373ce838f
dc.titleRole of VEGF in the differential growth between the fetal and placental ends of the umbilical cord
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datacite.rightshttp://purl.org/coar/access_right/c_16ec
oaire.resourceTypehttp://purl.org/coar/resource_type/c_6501
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.3233/NPM-1795
dc.subject.keywordsStillbirth
dc.subject.keywordsUmbilical cord
dc.subject.keywordsUmbilical cord length
dc.subject.keywordsVEGF
dc.subject.keywordsVasculotropin
dc.subject.keywordsVasculotropin A
dc.subject.keywordsVEGFA protein, human
dc.subject.keywordsAcidosis
dc.subject.keywordsAmnion
dc.subject.keywordsArticle
dc.subject.keywordsClinical article
dc.subject.keywordsCongenital heart malformation
dc.subject.keywordsDiaphragm hernia
dc.subject.keywordsDisease association
dc.subject.keywordsEndothelium
dc.subject.keywordsFemale
dc.subject.keywordsFetus growth
dc.subject.keywordsGestational age
dc.subject.keywordsHuman
dc.subject.keywordsHuman cell
dc.subject.keywordsHypoglycemia
dc.subject.keywordsImmunohistochemistry
dc.subject.keywordsIntrauterine growth retardation
dc.subject.keywordsMale
dc.subject.keywordsMaternal hypertension
dc.subject.keywordsNeonatal respiratory distress syndrome
dc.subject.keywordsNewborn
dc.subject.keywordsNewborn jaundice
dc.subject.keywordsObservational study
dc.subject.keywordsPlacenta
dc.subject.keywordsPlacenta development
dc.subject.keywordsPregnancy diabetes mellitus
dc.subject.keywordsPremature fetus membrane rupture
dc.subject.keywordsPriority journal
dc.subject.keywordsProtein expression
dc.subject.keywordsProtein function
dc.subject.keywordsStroma cell
dc.subject.keywordsUmbilical cord
dc.subject.keywordsUrinary tract infection
dc.subject.keywordsCell proliferation
dc.subject.keywordsControlled study
dc.subject.keywordsFetus
dc.subject.keywordsGene expression regulation
dc.subject.keywordsGrowth, development and aging
dc.subject.keywordsMetabolism
dc.subject.keywordsPhysiology
dc.subject.keywordsPregnancy
dc.subject.keywordsRandomized controlled trial
dc.subject.keywordsUmbilical cord
dc.subject.keywordsCell proliferation
dc.subject.keywordsFemale
dc.subject.keywordsFetus
dc.subject.keywordsGene Expression Regulation, Developmental
dc.subject.keywordsHumans
dc.subject.keywordsInfant, Newborn
dc.subject.keywordsPlacenta
dc.subject.keywordsPregnancy
dc.subject.keywordsUmbilical Cord
dc.subject.keywordsVascular Endothelial Growth Factor A
dc.rights.accessrightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.ccAtribución-NoComercial 4.0 Internacional
dc.identifier.instnameUniversidad Tecnológica de Bolívar
dc.identifier.reponameRepositorio UTB
dc.description.notesvasculotropin, 127464-60-2; vasculotropin A, 489395-96-2; Vascular Endothelial Growth Factor A; VEGFA protein, human
dc.type.spaArtículo
dc.identifier.orcid56461296300
dc.identifier.orcid57208213035
dc.identifier.orcid57208205059
dc.identifier.orcid6504810639
dc.identifier.orcid53871077300
dc.identifier.orcid57194148507


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Universidad Tecnológica de Bolívar - 2017 Institución de Educación Superior sujeta a inspección y vigilancia por el Ministerio de Educación Nacional. Resolución No 961 del 26 de octubre de 1970 a través de la cual la Gobernación de Bolívar otorga la Personería Jurídica a la Universidad Tecnológica de Bolívar.