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Genetic Advances in Post-traumatic Stress Disorder

dc.creatorGuillén-Burgos H.F.
dc.creatorGutiérrez-Ruíz, Karol
dc.date.accessioned2020-03-26T16:32:33Z
dc.date.available2020-03-26T16:32:33Z
dc.date.issued2018
dc.identifier.citationRevista Colombiana de Psiquiatria; Vol. 47, Núm. 2; pp. 108-118
dc.identifier.issn00347450
dc.identifier.urihttps://hdl.handle.net/20.500.12585/8887
dc.description.abstractPost-traumatic stress disorder, or PTSD, is a condition that affects a subgroup of individuals that have suffered a previous traumatic event capable of generating changes at a psychological and behavioural level. These changes affect the personal, family, and social environment of those who suffer from this condition. Different genes have been identified as risk markers for development of this disorder. The population heterogeneity and individual differences (genetic and environmental) of each subject have made it difficult to identify valid markers in previous studies. For this reason, studies of Gene x Environment (G × E) have gathered importance in the last two decades, with the aim of identifying of the phenotypes of a particular disease. These studies have included genes such as SLC64A, FKBP5, and ADCYAP1R1, among others. Little is known about the interaction between the genes, pathways, and the molecular and neural circuitry that underlie PTSD. However their identification and association with stimuli and specific environments that stimulate the development of PTSD makes it focus of interest for identify genomic variations in this disorder. In turn, the epigenetic modifications that regulate the expression of genes involved in the hypothalamic-pituitary-adrenal (HPA) axis and the amygdala- hippocampal-medial prefrontal cortex circuits play a role in the identification of biomarkers and endophenotypes in PTSD. In this review, the advances in genetic and epigenetic that have occurred in the genomic era in PTSD are presented. © 2016 Asociación Colombiana de Psiquiatríaeng
dc.format.mediumRecurso electrónico
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherElsevier Doyma
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourcehttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85009188290&doi=10.1016%2fj.rcp.2016.12.001&partnerID=40&md5=0ac50afc6e18ba156f7a767c45aacf1d
dc.titleGenetic Advances in Post-traumatic Stress Disorder
dc.title.alternativeAvances genéticos en el trastorno por estrés postraumático
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datacite.rightshttp://purl.org/coar/access_right/c_16ec
oaire.resourceTypehttp://purl.org/coar/resource_type/c_1843
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.driverinfo:eu-repo/semantics/other
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1016/j.rcp.2016.12.001
dc.subject.keywordsEpigenetics
dc.subject.keywordsGenetics
dc.subject.keywordsPost-traumatic stress disorder
dc.subject.keywordsAmygdala
dc.subject.keywordsDNA modification
dc.subject.keywordsEpigenetics
dc.subject.keywordsHippocampus
dc.subject.keywordsHypothalamus hypophysis adrenal system
dc.subject.keywordsMedial prefrontal cortex
dc.subject.keywordsPosttraumatic stress disorder
dc.subject.keywordsShort Survey
dc.subject.keywordsGene expression regulation
dc.subject.keywordsGenetic epigenesis
dc.subject.keywordsGenetic predisposition
dc.subject.keywordsGenetics
dc.subject.keywordsGenomics
dc.subject.keywordsGenotype environment interaction
dc.subject.keywordsHuman
dc.subject.keywordsMetabolism
dc.subject.keywordsPathophysiology
dc.subject.keywordsPhenotype
dc.subject.keywordsPosttraumatic stress disorder
dc.subject.keywordsRisk factor
dc.subject.keywordsBiological marker
dc.subject.keywordsBiomarkers
dc.subject.keywordsEpigenesis, Genetic
dc.subject.keywordsGene expression regulation
dc.subject.keywordsGene-Environment Interaction
dc.subject.keywordsGenetic Predisposition to Disease
dc.subject.keywordsGenomics
dc.subject.keywordsHumans
dc.subject.keywordsPhenotype
dc.subject.keywordsRisk Factors
dc.subject.keywordsStress Disorders, Post-Traumatic
dc.rights.accessrightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.ccAtribución-NoComercial 4.0 Internacional
dc.identifier.instnameUniversidad Tecnológica de Bolívar
dc.identifier.reponameRepositorio UTB
dc.description.notesBiomarkers
dc.type.spaEncuesta corta
dc.identifier.orcid57192927662
dc.identifier.orcid57192930752


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Universidad Tecnológica de Bolívar - 2017 Institución de Educación Superior sujeta a inspección y vigilancia por el Ministerio de Educación Nacional. Resolución No 961 del 26 de octubre de 1970 a través de la cual la Gobernación de Bolívar otorga la Personería Jurídica a la Universidad Tecnológica de Bolívar.