Listar Investigaciones por autor "Le-Thi-Thu H."

Mostrando ítems 1-4 de 4

    • Generalized molecular descriptors derived from event-based discrete derivative 

      Martínez-Santiago O.; Cabrera R.M.; Marrero-Ponce Y.; Barigye S.J.; Le-Thi-Thu H.; Torres, Javier; Zambrano C.H.; Yaber Goenaga, Iván; Cruz-Monteagudo, M.; López Y.M.; Giménez F.P.; Torrens, F. (Bentham Science Publishers B.V., 2016)
      In the present study, a generalized approach for molecular structure characterization is introduced, based on the relation frequency matrix (F) representation of the molecular graph and the subsequent calculation of the ...

    • Multi-output model with box-jenkins operators of quadratic indices for prediction of malaria and cancer inhibitors targeting ubiquitin-proteasome pathway (UPP) proteins 

      Casañola-Martín G.M.; Le-Thi-Thu H.; Pérez-Giménez F.; Marrero-Ponce Y.; Merino-Sanjuán M.; Abad C.; González-Díaz H. (Bentham Science Publishers B.V., 2016)
      The ubiquitin-proteasome pathway (UPP) is the primary degradation system of short-lived regulatory proteins. Cellular processes such as the cell cycle, signal transduction, gene expression, DNA repair and apoptosis are ...

    • Optimum search strategies or novel 3D molecular descriptors: Is there a stalemate? 

      Marrero-Ponce Y.; García-Jacas C.R.; Barigye S.J.; Valdés-Martiní J.R.; Rivera-Borroto O.M.; Pino-Urias R.W.; Cubillán, Néstor; Alvarado Y.J.; Le-Thi-Thu H. (Bentham Science Publishers B.V., 2015)
      The present manuscript describes a novel 3D-QSAR alignment free method (QuBiLS-MIDAS Duplex) based on algebraic bilinear, quadratic and linear forms on the kth two-tuple spatial-(dis)similarity matrix. Generalization schemes ...

    • Towards better BBB passage prediction using an extensive and curated data set 

      Brito-Sánchez Y.; Marrero-Ponce Y.; Barigye S.J.; Yaber Goenaga, Iván; Morell Pérez C.; Le-Thi-Thu H.; Cherkasov A. (Wiley-VCH Verlag, 2015)
      In the present report, the challenging task of drug delivery across the blood-brain barrier (BBB) is addressed via a computational approach. The BBB passage was modeled using classification and regression schemes on a novel ...

      Universidad Tecnológica de Bolívar - 2017 Institución de Educación Superior sujeta a inspección y vigilancia por el Ministerio de Educación Nacional. Resolución No 961 del 26 de octubre de 1970 a través de la cual la Gobernación de Bolívar otorga la Personería Jurídica a la Universidad Tecnológica de Bolívar.