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Ecotoxicological assessment of perchlorate using in vitro and in vivo assays

dc.creatorAcevedo Barrios, Rosa
dc.creatorSabater-Marco C.
dc.creatorOlivero-Verbel J.
dc.date.accessioned2020-03-26T16:32:33Z
dc.date.available2020-03-26T16:32:33Z
dc.date.issued2018
dc.identifier.citationEnvironmental Science and Pollution Research; Vol. 25, Núm. 14; pp. 13697-13708
dc.identifier.issn09441344
dc.identifier.urihttps://hdl.handle.net/20.500.12585/8882
dc.description.abstractPerchlorate is an inorganic ion widespread in the environment, generated as a natural and anthropogenic pollutant, with known endocrine disruption properties in the thyroid gland. Nonetheless, there are few reports of its ecotoxicological impact on wildlife. The aim of this study was to evaluate the adverse effects of KClO4 exposure on different cell lines, HEK, N2a, and 3T3, as well as in ecological models such as Vibrio fischeri, Pseudokirchneriella subcapitata, Daphnia magna, and Eisenia fetida. Perchlorate exhibited similar toxicity against tested cell lines, with LC50 values of 19, 15, and 19 mM for HEK, N2a, and 3T3, respectively; whereas in V. fischeri, the toxicity, examined as bioluminescence reduction, was considerably lower (EC50 = 715 mM). The survival of the freshwater algae P. subcapitata was significatively impaired by perchlorate (LC50 = 72 mM), and its effect on the lethality in the crustacean D. magna was prominent (LC50 = 5 mM). For the earthworm E. fetida, the LC50 was 56 mM in soil. In this organism, perchlorate induced avoidance behavior, weight loss, and decreased egg production and hatchling, as well as morphological and histopathological effects, such as malformations, dwarfism, and necrosis. In conclusion, perchlorate toxicity varies according to the species, although E. fetida is a sensitive model to generate information regarding the toxicological impact of KClO4 on biota. © 2018, Springer-Verlag GmbH Germany, part of Springer Nature.eng
dc.format.mediumRecurso electrónico
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherSpringer Verlag
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourcehttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85042767977&doi=10.1007%2fs11356-018-1565-6&partnerID=40&md5=5b305b162b9438486ee8f2659e4314ba
dc.titleEcotoxicological assessment of perchlorate using in vitro and in vivo assays
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datacite.rightshttp://purl.org/coar/access_right/c_16ec
oaire.resourceTypehttp://purl.org/coar/resource_type/c_6501
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.driverinfo:eu-repo/semantics/article
dc.type.hasversioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1007/s11356-018-1565-6
dc.subject.keywordsBiological models
dc.subject.keywordsBiota
dc.subject.keywordsEcotoxicology
dc.subject.keywordsEffects
dc.subject.keywordsEndocrine disruption
dc.subject.keywordsToxicity
dc.subject.keywordsAlga
dc.subject.keywordsAnthropogenic source
dc.subject.keywordsAssay
dc.subject.keywordsAssessment method
dc.subject.keywordsBacterium
dc.subject.keywordsBiota
dc.subject.keywordsCrustacean
dc.subject.keywordsEarthworm
dc.subject.keywordsEcological modeling
dc.subject.keywordsEcotoxicology
dc.subject.keywordsEndocrine disruptor
dc.subject.keywordsFreshwater environment
dc.subject.keywordsPerchlorate
dc.subject.keywordsPollution effect
dc.subject.keywordsAlgae
dc.subject.keywordsCrustacea
dc.subject.keywordsDaphnia magna
dc.subject.keywordsEisenia fetida
dc.subject.keywordsSelenastrum capricornutum
dc.subject.keywordsVibrio fischeri
dc.subject.keywordsPerchlorate
dc.subject.keywordsAnimal
dc.subject.keywordsAnimal model
dc.subject.keywordsBioassay
dc.subject.keywordsDrug effect
dc.subject.keywordsEcotoxicology
dc.subject.keywordsEnvironmental monitoring
dc.subject.keywordsHuman
dc.subject.keywordsOligochaeta
dc.subject.keywordsPollutant
dc.subject.keywordsProcedures
dc.subject.keywordsSpecies difference
dc.subject.keywordsToxicity
dc.subject.keywordsAnimals
dc.subject.keywordsBiological Assay
dc.subject.keywordsEcotoxicology
dc.subject.keywordsEnvironmental monitoring
dc.subject.keywordsEnvironmental Pollutants
dc.subject.keywordsHumans
dc.subject.keywordsModels, Animal
dc.subject.keywordsOligochaeta
dc.subject.keywordsPerchlorates
dc.subject.keywordsSpecies Specificity
dc.rights.accessrightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.ccAtribución-NoComercial 4.0 Internacional
dc.identifier.instnameUniversidad Tecnológica de Bolívar
dc.identifier.reponameRepositorio UTB
dc.description.notesperchlorate, 14797-73-0; Environmental Pollutants; perchlorate; Perchlorates
dc.type.spaArtículo
dc.identifier.orcid56674579200
dc.identifier.orcid57200990599
dc.identifier.orcid9736353600


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Universidad Tecnológica de Bolívar - 2017 Institución de Educación Superior sujeta a inspección y vigilancia por el Ministerio de Educación Nacional. Resolución No 961 del 26 de octubre de 1970 a través de la cual la Gobernación de Bolívar otorga la Personería Jurídica a la Universidad Tecnológica de Bolívar.